Abstract
New mesoporous silica nanoparticle (MSNs) with high surface area and pore volume has been synthesized successfully using TritonX-100 as main and Tween 60 as co-template (at various concentrations). Ibuprofen a water insoluble model drug was loaded into the synthesized silica nanoparticle and studied for sustained release capability. All the as synthesized and drug loaded nanoparticle were characterized using physicochemical techniques such as FTIR, Difuse reflectance UV spectroscopy(UV-DRS), Brunauer Emmett Teller (BET) technique, Differential Scanning Calorimetri ( DSC ),Thermo gravimetric analysis(TGA), powder XRD and scanning electron microscopy( SEM) for the morphology and drug loading. From the results it was noted that all the silica nanoparticle synthesized by sol-gel method were mesoporous with high surface area and pore volume (1024.3, 1056.2 and 1083.6 m 2 g -1 and 0.9229, 0.9904 and 0.8468 for TW6-1rt, TW6-2rt and TW6-3rt respectively) and have the capability of up taking 32 % ibuprofen model drug further they shows initial burst release for 50h followed by sustained maintenance of dose even after 150h.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.