Abstract
This article describes a convenient procedure for the synthesis of metal complexes of the type [ML] [CoMPQT](1), [NiMPQT](2) where M = Co(II), Ni(II) tetradentate (S2N2) Schiff-base using 3-[(2-[(2-mercaptoquinolin-3-yl)methylene]aminophenyl)imino]methyl quinoline-2-thiol ligand (MPQT)L. The synthesized ligand and its metal complexes were characterized by elemental analysis, FT-IR, 1H NMR, mass, and electronic spectra. The mode of bonding and the geometry of the complexes have been confirmed on the basis of IR and UV-vis spectral findings and magnetic measurements. The binding property of the complexes with calf-thymus DNA was studied by absorption spectra, viscosity measurements, and thermal denaturation studies. The intrinsic binding constant (Kb) had the value 2.8 × 104 M−1 for 1 and 4.8 × 104 M−1 for 2, suggesting that complex 2 binds more strongly to CT-DNA than complex 1. The synthesized metal complexes were screened for antibacterial and antifungal activities. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.
Published Version
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