Synthesis, characterization and cell imaging properties of rare earth compounds based on hydroxamate ligand

Abstract

Six binuclear rare earth compounds were synthesized through the ligand of 4-Bromo-N-hydroxy-N-methyl-benzamide (sH2bha). Compounds 1–3 are isomorphous, and compound 1 is crystallized in the monoclinic system with the P21/c space group. Compounds 4 and 5 are isomorphous, and compound 4 is crystallized in the triclinic system with the P-1 space group. Compound 6 is crystallized in the triclinic system with the P-1 space group. The compounds were characterized by thermogravimetric analysis (TGA) and IR spectroscopy. The fluorescence spectrum in the visible area shows characteristic peaks of Eu, Tb, and Dy compounds. The efficiency of Eu compound on the viability of PC3 cells was assessed using CCK8 assays. From the CCK8 results, ionic concentration may have a great effect on PC3 cells' proliferation. Eu compound shows red fluorescence in the cytoplasm of PC3 cell. As for Eu compound, it might have potential application in cell imaging technology.