Synthesis, characterization and biological studies of ferrocenyl complexes containing thiophene moiety

Abstract

A new ferrocenyl ligand was prepared from the condensation of 1,1′-diacetylferrocene dihydrazone with 2-thiophenealdehyde. The ligand, 1,1′-bis[(2-thienylmethylidene)hydrazono-1-ethyl]ferrocene, forms 1:1 complexes with cobalt(II), nickel(II), copper(II) and zinc(II) in good yield. Characterization of the ligand and complexes was carried out using IR, 1H NMR, electronic absorption and elemental analysis. Biological activity of the ligand and its complexes was assessed against Bacillus subtilis (+ve), Staphylococcus aureus (+ve), Candida albicans (yeast), Esherichia coli (−ve), Salmonella typhi (−ve), Aspergillus niger (fungi), and Fusarium solani (fungi). The biological results indicated that the complexes prepared are more active than the ligand. Copyright © 2005 John Wiley & Sons, Ltd.