Abstract
A novel heterocyclic library was synthesized, characterized and tested for biological evaluation against bacteria and fungus. This novel series of pyrazole pyrimidine derivatives of 5-(2-chlorophenyl)-2-(methylthio)-6-nitro-7-(2-oxo-1, 2- dihydroquinolin-3-yl)-4,7-dihydropyrazolo [1,5-a]pyrimidine-3-carbonitrile in the presence of methanoland hydrochloric acid in good yield. The title compounds have been synthesized with several structural variations. The synthesized compounds were screened for antimicrobial activity against standard drugs. The structure of synthesized compounds were characterized by their spectral (IR, 1H NMR and Mass) data. The purity of the synthesized compounds was confirmed by TLC.
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