Abstract
Objective: The main objective of the study is to synthesize some novel oxazolone derivatives to evaluate for anti-inflammatory activity.Methods: Acetylglycine was prepared using glycine and acetic anhydride, and the prepared acetylglycine was condensed with different aromatic aldehydes to get novel oxazolone derivatives. The synthesized compound was carried out the characterization by Fourier-transform infrared spectroscopy and find the anti-inflammatory by human red blood cell (HRBC) membrane stabilization method.Results: The anti-inflammatory activity was performed using novel oxazolone derivatives (Cpd1, Cpd2, Cpd3, and Cpd4) and nimesulide (as standard) on HRBC membrane stabilization method. The percentage protection was observed using colorimeter. The synthesized oxazolone was compared with the standard drug nimesulide for anti-inflammatory using HRBC membrane stabilizing method. All the synthesized oxazolone derivatives have shown the anti-inflammatory activity as that of standard. The results can be easily interpreted using histograms.Conclusions: Among all the synthesized compounds, oxazolone with 4-chlorobenzaldehyde shows more anti-inflammatory activity when compared with the other oxazolone derivatives.
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