Abstract
Ten novel transition metal complexes of N,O donor ligands have been synthesized by the reaction of ligands with metal acetates in 2:1 molar ratio. These reactions were carried out under reflux in methanol for 3-6 hours. The ligands and their transition metal complexes were characterized on the basis of physical properties, elemental analysis, Infrared spectroscopy, Magnetic susceptibility, Ultraviolet and Atomic absorption spectroscopy and 1H-13C NMR spectroscopy. The FT- IR spectra of the complexes indicated that ligands behaved in bidentate manner coordinating via the nitrogen and oxygen. 1H-NMR and 13C-NMR data of the ligands in pure and complex form confirmed the formation of the complexes. Other analytical techniques demonstrated that transition metal complexes of Cu, Ni, Co and Zn are four coordinated and those of Mn are six coordinated. Furthermore, antibacterial activities have been discussed.
Highlights
The preparation and study of inorganic compounds containing biologically important ligands is made easier, because certain metal ions are active in many biological processes; species of low molecular weight are, sought that reproduce, as far as possible, the structural properties and the reactivity of naturally occurring complexes of these ions in such processes
Schiff bases have a vital position in metal coordination chemistry even almost a century since their discovery
A number of metal coordination complexes of Schiff bases have been suggested as antibacterial, antifungal, cytotoxic, anti-inflammatory and Cytostatic agents. [3,4,5,6] In order to widen the scope of investigations on the coordination behavior of various donor ligands including Schiff base towards organo metallics, we carried out the investigations and established their bioactivities.[3,4,710]
Summary
The preparation and study of inorganic compounds containing biologically important ligands is made easier, because certain metal ions are active in many biological processes; species of low molecular weight are, sought that reproduce, as far as possible, the structural properties and the reactivity of naturally occurring complexes of these ions in such processes. The electronic absorption spectra of the ligands and complexes were recorded using DMSO as solvent on a UV-visible Spectrophotometer M/s Shimadzu 1600. The results of the elemental analysis and some physical characteristics of the obtained compounds are quite satisfactory (Table 1). Assignment of different vibration bands have been made by the comparison of ligand spectra with that of transition metal complexes.
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