Synthesis, Characterization and Biological Analysis of Some Novel Complexes of Phenyl Thiourea Derivatives with Copper

Neha Mathur,Nisha Jain,A.K Sharma

doi:10.2174/1874842201805010182

Abstract

Introduction: Copper is a very important metal because all forms of life require copper metals an essential micronutrient. Various biological processes, directly or indirectly are dependent on copper metal. Methods: Copper soaps are used as fungicides, bacteriosides, herbicides and insecticides. Copper complexes including heterocyclic compounds have attracted our attention in a magnificent way because of its utility in catalysis and biological functions. Their mechanism of synthesis, characterization and structural insight, are crucial for comprehending the criteria of the bonding and electronic interactions between the proximate metal center and chelating atoms. But still, there is a need to explore some of more biological properties for their wide applicability and significant usage in multiple fields because it is an untapped area with potentially tremendous value. Hence, in this paper, we report the synthesis and characterization of transition metal complex of N/S ligand by chromatographic, FT-IR, NMR, ESR, elemental analysis, conductometric and magnetic moment measurements. Results: The synthesized metal complexes namely copper palmitate with 4-nitrophenylthiourea and copper palmitate with 4-methoxyphenylthiourea were successfully investigated for biological activities against fungi Candida albicans and Trichoderma harzinum. Based on the results, we pronounced biocidal activities of the novel complexes. Conclusion: It is concluded that the activity of nitro phenylthiourea complex has greater antifungal activity than methoxy phenylthiourea complex against these test fungi. We can conclude that the antifungal activity of these complexes varies according to the nature of the groups attached to the ligands.

Highlights

Copper is a very important metal because all forms of life require copper metals an essential micronutrient
It is concluded that the activity of nitro phenylthiourea complex has greater antifungal activity than methoxy phenylthiourea complex against these test fungi
We can conclude that the antifungal activity of these complexes varies according to the nature of the groups attached to the ligands

Summary

Introduction

Copper is a very important metal because all forms of life require copper metals an essential micronutrient. The present research is an important effort to understand the characteristic nature and biocidal application of copper complexes of nitrogen donor ligands. The role of benzoyl thiourea derivatives in co-ordination chemistry has been extensively studied and quite satisfactorily elucidated. New thiourea derivatives and their structures have received attention because of their wonderful complexation capacity [5]. Various physical properties i.e. density, viscosity, fluidity of the complexes in non -aqueous medium (Propanol + Benzene) have been investigated to determine critical micelle concentration [6]. These physical parameters are used to understand molecular interactions between the components of the mixture [7]. In the present study antifungal activity was performed for the synthesized complexes CP(PTU)NA, CP(PTU)A, on Muller Hinton Agar against Candida albicans, Trichoderma harzianum Abbreviation of complexes as follows: CP[PTU]NA: Complex of Cu (II) Palmitate with 4-nitrophenylthiourea

Methods

Results

Conclusion