Abstract
4-vinyl pyridine nickel complex containing polymerizable vinyl group, prepared by condensing (4:1 molar ratio) of 4-vinylpyridine with Nickel chloride, then polymerized with methyl methacrylate at 70 °C using AIBN as initiator. Metal complexand polymer metal complex have been characterized by elemental analyses, molar conductance, IR, 1H-NMR , Massspectra and thermal analyses (DTA and TGA). Conductivity measurement reveals the nonelectrolytic nature of thecomplex. This confirms that, the anion is coordinated to the metal ion. The IR reveal the metal ion is coordinated via thenitrogen atom of 4-VP. Nickel complex and polymer nickel complex have been tested invitro against number of tumor andnumber of microorganisms in order to assess their anti tumor and antimicrobial properties. The antimicrobial activity wasobserved by compounds VP-Ni and MMA-VP-Ni under the screening conditions. The activity against HCT-116 cells wasdetected for compound VP-Ni (with IC50 value 9.8±0.6 µg/ml), compared with reference standard (24.6±0.3 µg/ml) followedby MMA-VP-Ni (48.3±1.5). In conclusion, this study highlighted the synthesis of polymer nickel complex, and proved thepromising biological activity of the synthesized compounds.
Highlights
Late transition metal complexes [1], due to their less oxophilic nature relative to early transition metal complexes[2] and lanthanide metal complexes [3], are generally considered to be more tolerant toward polar functional monomer, which makes them likely targets to the development of catalysts for the polymerization of polar monomers including methyl methacrylate (MMA)
Antimicrobial activity of tested metal complex and polymer metal complex were assessed against four bacterial strains (Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus pneumoniae) and two fungal strains (Aspergillus fumigatus and Candida albicans)
Polymerisable metal complex synthesized by reaction of VP-Ni complex with methyl methacrylate in presence of AIBN as initiator
Summary
Late transition metal complexes [1],, due to their less oxophilic nature relative to early transition metal complexes[2] and lanthanide metal complexes [3], are generally considered to be more tolerant toward polar functional monomer, which makes them likely targets to the development of catalysts for the polymerization of polar monomers including methyl methacrylate (MMA). Nickel (II) complexes bearing N, O-chelate ligand activation for MMA polymerization yielded poly (methyl methacrylate) (PMMA) with rich syndiotacticity microstructure [4,5,6,7,8,9,10]. The chelating polymers find applications in bioinorganic industry [11], wastewater treatment [12,13], pollution control [14], hydrometallurgy [15], preconcentration [16], anionic polyelectrolyte hydrogels [17], cation-exchange resins [18] , showed potential applications in material science as conductive [19], luminescent [20], magnetic, porous, chiral or non-linear optical materials [21], catalytic [22,23,24,25],organic synthesis [26], polymer drug graft, recovery of trace metal ions [13] and antimicrobial activities [27,28]
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