Abstract
A novel series of metal complexes of guanidine ligand derived from condensation of 1,1,3,3-tetramethylurea and 2-aminopyridine in present of POCl3 have been synthesized. The complexes are characterized using FTIR, UV-Vis and also molar conductance was measured. These spectroscopic studies confirmed that the ligand bonded to the metals through the nitrogen atoms. The suggested structures of the metal complexes are square planner. The ligand and its metal complexes were tested against Gram-negative bacteria; Escherichia coli, Serratia marcescens and Gram-positive bacteria; Bacillus sabtilis and Staphylococcus aureus by applying disc diffusion method. The most antibacterial activity of synthesized compounds belongs to CdL2 complex. The results of this study showed that the metal complexes have more antibacterial activity against species when compared to the parent ligand.
Highlights
Bacterial infections and bacteria drug resistance are very common all around the world
The ligand and its metal complexes were tested against Gram-negative bacteria; Escherichia coli, Serratia marcescens and Gram-positive bacteria; Bacillus sabtilis and Staphylococcus aureus by applying disc diffusion method
The antibacterial activity of synthesized compounds were evaluated against two gram positive (Bacillus sabtilis, Staphylococcus aureus) and two gram negative (Escherichia coli, Serratia marcescens) bacterial strains using disc diffusion method
Summary
Bacterial infections and bacteria drug resistance are very common all around the world. Guanidine, has already gained excessive attention since its discovery, due to their chemical and biological properties (Manetti et al, 2009) They appear in a number of important antibiotic drugs including: Streptomycin, Trimethoprim, Chlorhexidine, Polyhexamethylene bi guanidine, Pyrrplidine bis-cyclic guanidine and others (Ghulam Murtaza, 2012). Transition metal complexes derived from guanidines have been found to exhibit some biological properties like antibacterial and antifungal activities (Cesme et al, 2015). The important pathogens such as Escherichia coli, Serratia marcescen, Bacillus sabtilis, and Staphylococcus aureus have wildly caused many diseases, so antibacterial activity of these complexes against four kinds of bacteria have been established. The antibacterial activity of synthesized compounds compared to standard antibiotic drugs against gram-negative and gram-positive bacterial strains
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