Abstract
A novel fullerene-maleic anhydride derivative was synthesized via radical polymerization. It is soluble in polar solvents such as water, dimethyl sulfoxide, and tetrahydrofuran etc. The product was characterized by FTIR, UV-Vis, GPC, and Transmission electron microscope (TEM). TEM analysis shows that the average particle diameter is about 38 nm. The in vitro antitumor activity of the fullerene-maleic anhydride derivative has been tested and the result shows that the derivative exhibits better antitumor activity against HeLa cells and bone tumor cells. To prove water-soluble fullerene derivatives photodynamic effect on tumor cell, i.e., the photodynamic effect on mouse bone tumor in vivo we injected the fullerene -maleic anhydride derivatives into the mouse bone tumor body. We found that with I-W lamp (500 W) illumination the mouse bone tumor body was strongly damaged. The antitumor mechanism of water-soluble fullerene-maleic anhydride derivative was investigated for the first time. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007
Published Version
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