Abstract

A new SNS trifentate ligand containing piperidine group as pendant amine, N,N-bis(2-mercaptoethyl)(2-piperidin-1-ylethyl)amine, was synthesized by alkylation of bis(2-benzylthioethyl)amine with 1-(2-chloroethyl)piperidine in the presence of NaI, and deprotection of the thiols using Na/NH3. Three neutral oxotechnetium mixed ligand complexes [SNS/S] with either p-toluenethiol, benzylmercaptan, or p-methoxybenzylmercaptan, were synthesized at carrier level [99Tc] and characterized by elemental analysis, UV-vis, IR and 1H NMR spectroscopies. The complex with p-toluenethiol as coligand was also characterized by x-ray crystallography. The same complexes were also prepared at tracer level [99mTc], and their in vivo biodistribution was investigated in mice. All 99mTc complexes have fast blood clearance, high uptake and significant retention into the brain. Copyright © 1999 John Wiley & Sons, Ltd.

Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call