Synthesis, characterization, and bioactivity of several metal complexes of (4-Amino-N-(5-methyl-isaxazol-3-yl)-benzenesulfonamide)

Abstract

• 4-Amino-N-(5-methyl-isaxazol-3-yl)-benzenesulfonamide was synthesized. • All complexes were found to possess a 1:2 metal–ligand ratio and non-electrolytes. • Au(III) complex electrolyte [1:1], according to analytical studies. • The biological activities of four species of fungi were also studied. 4-Amino-N-(5-methyl-isaxazol-3-yl)-benzenesulfonamide was synthesized by reacting the diazonium salt of sulfamethoxazole with 3-amino phenol. Complexes of Ni(II), Pd(II), Au(III), and Pt(IV) were produced and characterized by atomic absorption, elemental microanalysis, infrared spectroscopy, liquid chromatography–mass spectroscopy, thermogravimetric analysis, different scanning calorimetry, and ultraviolet–visible spectroscopy. Furthermore, the conductivity and magnetic properties were quantified. According to the analytical studies, all complexes were found to possess a 1:2 metal–ligand ratio and were non-electrolytes, except the Au(III) complex electrolyte, which had a 1:1 metal:ligand ratio. The biological activities of some of the compounds against two types of bacteria and two species of fungi were also studied, resulting in varying inhibition values.