Synthesis Characterization and Antimicrobial Activity of Metal Chelates of 1, 7-Di (2-hydroxyphenyl) 1, 7 di (N-methyl) aza-1, 3, 5 heptarine-3-ol hydrochloride

Nalin P Patani,M V Hathi

doi:10.1155/2010/587615

Abstract

The Schiff base complexes derived from 2-furancarboxaldehyde and N-methyl-2-amino phenol have been prepared and characterized using several physical techniques, like elemental analysis, thermogravimetric analysis, magnetic moment measurements, infrared and resonance spectra.N-Methyl-2-amino phenol was condensed stoichiometrically with 2-furancarboxaldehyde in presence of methanol. The resulting 1,7-di(2-hydroxyphenyl) 1,7 di(N-methyl) aza-1,3,5 heptarine-3-ol hydrochloride was characterized by elemental analysis and spectral studies. The transition metal complexes of Cu2+, Zn2+, Ni2+, Co2+and Mn2+of the synthesized complexes were prepared. Metal ligand (M:L) ratio, IR, reflectance spectral studies, magnetic properties and antimicrobial activity of the synthesized complexes and its metal complexes were carried out.

Highlights

The Schiff base complexes derived from 2-furancarboxaldehyde and N-methyl-2-amino phenol have been prepared and characterized using several physical techniques, like elemental analysis, thermogravimetric analysis, magnetic moment measurements, infrared and resonance spectra
2- Furancarboxaldehyde is well known as an analytical reagent[1,2]
The complexes obtained from ligands having methyl, ethyl, nitro as functional group[4] have been investigated exhaustively

Summary

Introduction

The Schiff base complexes derived from 2-furancarboxaldehyde and N-methyl-2-amino phenol have been prepared and characterized using several physical techniques, like elemental analysis, thermogravimetric analysis, magnetic moment measurements, infrared and resonance spectra. The complexes obtained from ligands having methyl, ethyl, nitro as functional group[4] have been investigated exhaustively. The present communication describes the synthesis and characterization of 1,7-di(2hydroxyphenyl) 1,7 di(N-methyl)aza-1,3,5 heptarine-3-ol hydrochloride and its complexes with Cu2+, Zn2+, Ni2+ and Co2+ antimicrobial activities of these complexes. To a solution of (0.1 M) N-methyl-2-amino phenol in methanol, a solution of 2- furancarboxaldehyde (0.05 M) in methanol was added drop wise within 20 minutes.

Results

Conclusion