Abstract
This report describes the synthesis of a bimetallic cobalt-copper complex of histidine-containing β-cyclodextrin (βCDhis) capable of efficiently scavenging superoxide radicals and peroxide anions. A blue-violet CoCu/(βCDhis) complex was prepared in mole ratios of 0.165:0.25:1:1 of Co:Cu:his:βCD in water and characterized using UV–vis, TGA-DTA, EDX, powder XRD and FT-IR analytical techniques. TGA analysis and XRD patterns showed that histidine was incorporated within the β-cyclodextrin ring. UV–Vis and FT-IR spectroscopy confirmed that the histidine CO group interacts with copper and cobalt metals. The results of antioxidant activity tests showed that CoCu/(βCDhis) complex has the highest catalase (88 %), and peroxidase activity (87 %) per 0.005 g of the complex. The imidazole group in histidine increases the solubility of the synthesized complexes and the ability to scavenge hydroxyl radicals, therefore histidine enhances their antioxidant potential.
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