SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF [1,2,4 (H)] TRIAZOLE3-AMINE AND ITS DERIVATIVES.

Abstract

In this research article we synthesized 1,2,4 (H) triazole 3-amine as a core molecule from aminoguinidine and formic acid in basic medium sodium 0 carbonate heated at 120-123 C for 12 h. It has excellent medicinal application. In synthetic modication especial emphasis on free –NH as a20 pharmacophore which is synthetically active group. A series of 03 innovative molecules were synthesized by isocyanate in ethanol solvent at 0 C to room temperature, 2 h. Urea as important moiety found in synthesized molecule. The purity of all compounds will be checked by TLC and wherever found necessary the compounds will be puried by column chromatography. The structure of all compounds will be established on the 1 13 basis of microanalysis, FTIR, HNMR, CNMR, DEPT and mass spectral data. Antibacterial and antifungal evaluation of synthesized derivatives in vitro has done by Kirby Bauer Method. NCIM provides pure, non-pathogenic, viable and authentic cultures with their standard code number and testing symbols; Ciprooxacin (10 lg) and uconazole (5 lg) were used as standard antibacterial and antifungal drugs, respectively. Minimum zone of inhibition & % activity has been determined; from these values its predicted that antibacterial value of the derivatives are more prominent that core molecule against Gram positive bacterial strains Staphylococcus aureus & Bacillus subtilis. Antifungal activity is more prominent in TZA2 derivative where urease moiety connected with cyclohexyl group against Aspergillus niger & Penicillium Chrysogenum