Abstract
A series of new coordination complexes of Cu(II), Co(II), Ni(II), Zn(II), Hg(II), Mn(II), and Fe(III) with the Schiff base 3-chloro-N′-[(1E)-(2-hydroxy phenyl)methylene]-6-methoxy-1-benzothiophene-2-carbohydrazide (HL) have been synthesized and characterized by elemental analysis, electrical conductivity measurements, IR spectra, 1H NMR, mass spectral data, electronic spectra, magnetic susceptibility, ESR spectra, TGA, and Powder XRD data. The Schiff base behaves as tridentate ONO donor ligand and forms the complexes of the type ML2 (metal-ligand) stoichiometry for Cu(II), Co(II), Ni(II), and Mn(II) complexes and ML stoichiometry for Zn(II), Hg(II), and Fe(III) complexes. All the complexes are colored and nonelectrolytes. It is found that Cu(II), Co(II), Ni(II), Mn(II) and Fe(III) complexes have exhibited octahedral geometry whereas Zn(II) and Hg(II) complexes exhibited tetrahedral geometry. The ligand and its metal complexes have been screened for their antibacterial activity against E. coli and S. aureus and antifungal activity against A. niger and A. flavus.
Highlights
Metal complexes with potentially tridentate and tetradentate ligands have evoked much interest in coordination chemistry [1]
To the hot solution of 3-chloro-N-[(IE)-(2-hydroxy phenyl)methylene]-6-methoxy-1-benzothiophene-2-carbohydrazide (HL) (Figure 10) (0.002 mol) in ethanol (30 mL) was added a hot ethanolic solution (10 mL) of respective metal chloride (0.002 mol); the reaction mixture was refluxed on a steam bath for 4 h, sodium acetate (0.5 g) was added to it and refluxed for further 2 h
In the light of above discussion we have proposed that Cu(II), Co(II), Ni(II), Mn(II), and Fe(III) complexes have exhibited octahedral geometry whereas Zn(II) and Hg(II) complexes exhibited tetrahedral geometry
Summary
Metal complexes with potentially tridentate and tetradentate ligands have evoked much interest in coordination chemistry [1]. Literature survey reveals that many benzothiophene [8,9,10] derivatives are known to possess good biological activities like antimicrobial, anti-inflammatory, analgesic, diuretic, and antiviral activities. In view of these findings and in continuation of our research work on coordination chemistry [11,12,13,14,15,16], we are reporting the synthesis, characterization, and antimicrobial activity of Cu(II), Co(II), Ni(II), Zn(II), Hg(II), Mn(II), and Fe(III) complexes of 3-chloro-N-[(1E)-(2hydroxy phenyl)methylene]-6-methoxy-1-benzothiophene2-carbohydrazide (HL) (Figure 9) in this communication (H refers to phenolate)
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