Abstract
Background: Selenium nanoparticles have been studied for possible therapeutic effects in a variety of oxidative stress and inflammation-mediated diseases such as arthritis, cancer, diabetes, nephropathy, as well as antimicrobial properties. Clitoria ternatea is a perennial herbaceous plant which has been documented for its antimicrobial properties that are beneficial to human health. Therefore, this study was designed to synthesize, characterize and investigate the synergistic antimicrobial activity of selenium nanoparticles with Clitoria ternatea on oral pathogens. Materials and method: Green synthesis of selenium nanoparticles was achieved by a simple biological procedure using the reducing power of Clitoria ternatea flower extract. The synthesized nanoparticles were characterized using UV-vis-spectroscopy and Transmission Electron Microscopy. The antimicrobial activity was assessed using agar well diffusion method against strains of S.aureus, S.mutans, E.faecalis and C.albicans. Results: The synthesised nanoparticles showed potential antimicrobial activity against strains of gram positive bacteria especially against S.aureus where 35 mm of inhibitory activity was observed. They also showed enhanced antifungal property as compared to the control.
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