Abstract
A novel mixed ligand complexes having the formulae [Cu(L1)2(H2O)2]Cl2 and [Cu(L1)2L2H2O]Cl (L1 = 1,10-phenanthroline, L2 = thymine) have been prepared and characterized by various physicochemical studies such as elemental analysis, molar conductance in nonaqueous solvent, infrared and electronic spectra. Both the ligands as well as the metal complexes were used further to investigate the biological activities (antibacterial) against Staphylococcus aureus (SA) (ATCC 25923), Streptococcus pneumonia (SP) (clinical isolate), methicillin-resistant Staphylococcus aureus (MRSA) (clinical isolate), Klebsiella pneumoniae (KP) (clinical isolate), Escherichia coli (EC) (clinical isolate), and Shigella boydii (SBD) (ATCC 12022). On comparing the biological activities, the complexes showed enhanced antimicrobial activity compared to the free metal salt with thymine being lower than that of 1,10-phenanthroline.
Highlights
The therapeutic and diagnostic properties of transition metal complexes have attracted considerable attention leading to their application in many areas of modern medicine [1]
Synthesis and characterization studies The formation of the complexes can be represented by the following equations and Scheme 1: CuCl2 · 2 H2O + 2 L1 −→ Cu(L1)2(H2O)2Cl2, (1)
Complex 1 is a greenish, nonhygroscopic solid. It is soluble in water and acetonitrile but insoluble in acetone and methanol; whereas complex 2 is a deep blue nonhygroscopic solid that is soluble in water, dichloromethane, and acetonitrile but insoluble in acetone and methanol
Summary
The therapeutic and diagnostic properties of transition metal complexes have attracted considerable attention leading to their application in many areas of modern medicine [1]. Many coordination compounds of transition metal ions are feasible for nucleolytic cleavage. In this regard, mixed ligand metal complexes are found to be useful because of their potential binding ability to DNA [2]. A significant advantage in the use of these metallo-intercalators for such studies is that both the ligands and the metal ion can be varied in an controlled manner to facilitate individual applications [3]. The metal complexes have higher activity than that of the free ligands This is probably due to the larger lipophilic nature of the complexes. Such an increased activity of the metal chelate can be explained on the basis of overtones concept and chelation theory [1]
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