Abstract
Co(II), Ni(II), and Cu(II) complexes of aroylhydrazone mixed with aspirin were synthesized and characterized by percentage metal analysis, infrared and electronic spectroscopy, melting point, solubility, molar conductance and room temperature magnetic moment measurements. Infrared spectra data revealed that the aspirin behaved as a bidentate ligand with coordination via carboxylate and carbonyl groups while the hydrazine coordinated via the azomethine nitrogen atom and carbonyl oxygen atom in the aroylhydrazone. The room temperature magnetic moment and electronic spectral data that the metal complexes possessed octahedral geometry. The molar conductance measurements of all the metal complexes in DMF indicated that they are non-electrolytes. The in vitro antimicrobial activities studies showed that the Cu(II) complex had the best activity against tested bacteria; Streptococcus spp, B. subtlis and vibro spp with inhibitory zones range of 2.0 - 6.0 mm, while the Ni(II) complex showed considerable activity against gram negative bacteria; Shigella spp with inhibitory zone of 10.0 mm suggesting its potential as an antimicrobial agent.
Highlights
The coordination chemistry of mixed ligands is an intensive area of study and numerous transition metal complexes of mixed ligands have been investigated [1]
Aroylhydrazones are aromatic hydrazones which belong to a class of organic compounds in the Schiff base family with the functional group R1−CO−NH−N=CH−R2
There are works reported in literature on metal complexes of aroylhydrazone and Aspirin independently, but little is known on the mixed metal(II) complexes of aroylhydrazone with Aspirin [3,4,5,6,7,8,9,10,11,12,13,14]
Summary
The coordination chemistry of mixed ligands is an intensive area of study and numerous transition metal complexes of mixed ligands have been investigated [1]. The hydrazone Schiff base of aroyl, acyl, and heteroaroyl compounds are known to have an additional donor site, that is C=O, which make them more versatile and flexible. This versatility has led to their emergence as good chelating agents that can form a variety of complexes with different transition metals [2]. In this work, we synthesized, characterized and investigated the antimicrobial activities of Co(II), Ni(II), and Cu(II) complexes of aroylhydrazone mixed with aspirin
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