Abstract
Platinum(II) complexes of heterocyclic thiones (L) based on transplatin having the general formula, trans-[Pt(NH3)2(Thione)2](NO3)2 have been synthesized and characterized using elemental analysis, IR, and NMR (1H &13C) spectroscopy. The crystal structures of two of them, trans-[Pt(NH3)2(Imt)2](NO3)2 (1) and trans-[Pt(NH3)2(Me2Imt)2](NO3)2 (3) were determined by X-ray crystallography. The structures of 1 and 3 consist of trans-[Pt(NH3)2L2]2+ complex ions and nitrate counter ions. The platinum atom in both the complex ions adopts a distorted square planar geometry. The spectroscopic data indicated the coordination of thione ligands to platinum(II). The in vitro cytotoxicity of these compounds as well as of cisplatin and carboplatin was investigated using MTT assay against three human cancer cell lines, which are; A549 (lung carcinoma), MCF-7 (breast carcinoma) and HTC15 (colon cancer). The in vitro cytotoxicity in several cases is comparable or even higher, than carboplatin and in two cases than cisplatin.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
