Abstract
Abstract Copper (I), nickel (I) and zinc(I) complexes with the Schiff base derived from 2,4-dihydroxybenzaldehyde and L-arginine have been synthesized and characterized by elemental anlyses, TG-DTA, IR, electronic spectra and conductivity measurements. The Schiff base ligand has been further characterized by 1HNMR. The results suggest that the Schiff base acts as tridental ligand. The electronic spectra of DNA-complexes and the fluoresence spectra of DNA-EthBr (ethidium bromide)-complexes indicate that the complexes of copper(I), nickel(I) and zinc(I) intercalate DNA. The test of anticancer activity in vivo shows that their cancer inhibition rates to EAC (Ehrlich ascites carcinoma) are 53. 3%, 51. 7% and 32. 2%, respectively.
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