Abstract
The Schiff bases (A1- A5) were produced from the reaction of the 5-aminosalicylic acid with a variety of aldehydes by microwave method. Schiff bases were reacted with thioglycolic acid to obtain thiazolidine-4-one compounds (A6 – A10). Imidazolidine-4-one compounds (A11 - A15) were prepared from the prepared Schiff bases with the amino acid (alanine). Spectroscopic methods were used to diagnose the produced compounds (IR, 1H-NMR). The biological activity against two types of bacteria Proteus mirabilis –GVe and Enterococcus faecalis +GVe have tested and compared with the Mesalazine drug. The results proved that some of the prepared compounds are effective against these bacteria at different concentrations of 5 mg/ml, 10 mg/ml, and 15 mg/ml.
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