Synthesis, Characterization and Antibacterial Activity of Some Halo Substituted Schiff Bases

S B Junne,Y B Vibhute,S L Shinde,G S Waghamare,Archana B Kadam

doi:10.1155/2010/571309

Abstract

Some new halo substituted Schiff bases have been prepared from different aromatic aldehydes and a series of substituted aromatic amines to form a number of potentially biologically active compounds. The structures of the Schiff bases have been characterized by using IR and1HNMR spectroscopy. These compounds were screened against human pathogenic bacteria by agar diffusion method. Ampicillin was used as control.

Highlights

New halo substituted Schiff bases were used as substrates in the preparation of number of biologically active compounds[1]
Present study of Schiff bases have been synthesized by refluxing a mixture of different aromatic aldehydes with substituted aromatic amines and few drops of acetic acid in methanol[12]
All these compounds were screened against human pathogenic bacteria i.e. Dermatophillus congolensis, Proteus vulgaris, Staphylococcus aureus, Corynebacterium

Summary

Introduction

New halo substituted Schiff bases were used as substrates in the preparation of number of biologically active compounds[1]. Schiff bases were known to have biological activities such as antimicrobial[2,3,4,5], antifungal[4,5,6], antitumor[7,8,9] and herbicides[10]. They were used as starting materials for synthesis of various biologically active heterocyclic compounds[11]. Present study of Schiff bases have been synthesized by refluxing a mixture of different aromatic aldehydes with substituted aromatic amines and few drops of acetic acid in methanol[12].

Results

Conclusion