Abstract
Pyrazole derivatives are pharmacologically important agents that possess a wide spectrum of biological activities. Thus, the optimization of their synthetic approaches is of great interest for medicinal and pharmaceutical chemistry. In this work, eleven new 7-aryl-2,3-dihydro-7H-imidazo[1,2-c]pyrazolo[4,3-e]pyrimidines 1(a-k) were synthesized employing microwave irradiation conditions (150 W, 15–45 min). All compounds were completely characterized through Fourier Transform Infrared Spectroscopy (FT-IR), Nuclear Magnetic Resonance (NMR), and High-resolution Mass Spectrometry (HRMS) analyses. The in silico prediction of physicochemical properties showed that all analogs do not violate Lipinki's rule with prediction of good oral bioavailability. Analogs showed low activity against T. cruzi. Correlated experimental methods have been applied to investigate the photophysical properties of 1(a-k), describing their absorption properties in function of substituents. The molecular set exhibits a cyan emission, enabling it to investigate the basic fluorescence spectroscopy in solution.
Published Version
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