Abstract
A-B-A-type block copolymers were prepared by the polymerization of γ-benzyl L-glutamate NCA (A segment) using polyoxypropylene (POP, B segment) with amino groups at both ends of a chain as an initiator. Thrombus formation on the block copolymer films was minimum on a block copolymer containing a POP segment of 50 mol%. It was found that on the block copolymer, denaturation of plasma proteins such as albumin and fibrinogen upon adsorption was sufficiently low not to activate adhered platelets, leading to a low degree of thrombogenesis. The oxygen permeation coefficients (P) of block copolymer films in water were about twice as large as that of poly(γ-benzyl L-glutamate) (PBLG) film. The increased permeation was ascribed to an increased diffusion coefficient (D) of dissolved oxygen through the block copolymer films. Arrhenius plots of P and D showed a break point in the temperature range of 20–30°C. At lower temperatures than the break temperature, the activation energy for oxygen permeation of the block copolymer film was lower than that of PBLG film.
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