Synthesis, biological evaluation of substituted indol-2,3-dione and 2,2-dimethylpropane-1,3-diamine Cu(II), NI(II) and Fe(II) metal complexes

Abstract

A series Schiff base macrocyclic complexes of the type [HLMX2] where M = Cu(II), Ni(II), Co(II) and X = Cl, OAc have been synthesized by condensation of 5-methylindoline- 2,3-dione and 2,2-dimethylpropane-1,3-diamine in the presence of divalent metal salt in methanolic medium. The complexes have been characterized with the help of elemental analysis, conductance measurements, magnetic measurements and their structural configuration have been determined by various spectroscopic (electronic, IR, 1H NMR, 13C NMR, GCMS) techniques. Electronic and magnetic moments of the complexes indicate that the geometries of the metal centers are octahedral. These metal complexes were also tested for their antimicrobial activities to assess their inhibiting potential.