Abstract
Synthesis of new bis-N-imino triazole derivatives containing oxadiazole 2, its Mannich base 3, and the S-alkyl group 4 is presented. Bis-N-iminotriazole 2 is formed in the reaction of compound 1 with terephthalaldehyde. Bis N-iminotriazole derivatives containing Mannich base 3 are synthesized by the reaction of morpholine or piperidine with the compound 2. The compound 2 also reacts with alkyl halides (butyl, pentyl, hexyl, heptyl) to give S-alkylated bis-N-imino triazoles 4. Structures of the new compounds are characterized by IR, 1H, and 13C NMR, and mass spectral data. Antioxidant (FRAP and DPPH assay) and antileishmanial activities tests of the compounds indicate that the products 2, 3a, and 3b demonstrate moderate antioxidant activity in both DPPH and FRAP assays. The antileishmanial tests indicate high activity of the compounds 3a and 3b.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
