Synthesis, anti-microbial activity and molecular docking studies on triazolylcoumarin derivatives

Abstract

A series of triazolylcoumarins was synthesized by the cycloaddition of acetylenic derivatives to azide in the presence of Cu(I) catalyst at room temperature. All the synthesized compounds were evaluated for their anti-microbial activity against Gram-positive (B. subtilis and S. aureus), Gram-negative bacteria (K. pneumonia and P. vulgaris) and human pathogenic fungi (C. tropicalis and C. krusei), with tetracycline and fluconazole as standards for anti-microbial and anti-fungal activity. Triazolylcoumarins exhibit anti-microbial activity against all the tested pathogens, which is further supported by molecular docking studies. A series of triazolylcoumarins was synthesized using click chemistry approach. All the triazolylcoumarin compounds were evaluated for their anti-microbial activity against Gram-positive, Gram-negative bacteria and human pathogenic fungi, with tetracycline and fluconazole as standards as supported by molecular docking studies.