Abstract
Palladium(II) and cobalt(II) complexes of Schiff base derived from 4-aminobenzene sulfonamide (Sulfonamide drug) were prepared by convenient method. Reaction of sulfonamide with 2-hydroxy-1-naphthaldehyde gave the Schiff base compound 1 in good yield. Treatment of compound 1 with CoCl 2 .6H 2 O and PdCl 2 yielded new metal complexes 2 and 3 , respectively. The synthesized compounds were screened for their antibacterial activity against Escherichia coli , Bacillus cereus , Salmonella spp. and Staphylococcus aureus . Additionally, the compounds were tested for antifungal activity against Aspergillus niger and Candida albicans . Some compounds exhibited good antibacterial and antifungal activity. Molecular modeling studies were performed and showed hydrogen binding and hydrophobic interactions.
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