Abstract

In the present work, six new cobalt(II) complexes (1-6) of (E)-2-(2-hydroxy-3-methoxybenzylidene)-N4-methylhydrazinecarbothioamide (HL1), (E)-2-(2-hydroxy-3-methoxybenzylidene)-hydrazinecarbothioamide (HL2) and (E)-2-(2-hydroxy-3-methoxybenzylidene)-hydrazinecarboxamide (HL3), have been synthesized and characterized. The FT-IR spectral data suggested the attachment of cobalt(II) ion to the Schiff’s base ligand moiety through the azomethine nitrogen, thioketonic sulfur and phenolic-O atom. The synthesized complexes 1-6 were tested for their antibacterial activities against two gram-positive bacteria (Bacillus subtilis and Escherichia coli) and two gram-negative bacteria (Pseudomonas aeruginosa and Staphylococcus aureus) and also screened for their antifungal activity against Aspergillus Niger and Candida Albicans. These complexes showed moderate to considerable effect on bacteria strains, whereas they showed moderate effect on fungal strains.

Highlights

  • 15ml of the ethanol-acetonitrile (2:3) mixture of 0.0011 mole of ligands and 10 ml of the mixture of the ethanol acetonitrile of 0.0005 mole (0.0649g) CoCl2 were mixed

  • Antimicrobial activity of Schiff base ligands L1- L3 were reported in our previous work . [1,2,3]

  • P, Chithra K, Kannan S, Shanthi W., Saravanan R, Suresh M and Satheesh D, J Pharm Chem Biol Sci 2017; 5(3):205215

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Summary

Aim:

To synthesize and characterization of six new Cobalt(II) complexes of (E)-2-(2hydroxy-3-methoxybenzalidene)hydrazinecarbo(thio)amides. In our previous work, the three Schiff base ligands namely as (E)-2-(2-hydroxy-. 3-methoxybenzalidene)-N4-methylhydrazinecarbothioamide (HL1), (E)-2-(2- Chemistry hydroxy-3-methoxybenzalidene)-hydrazinecarbothioamide (HL2) and (E)-2-(2-. Hydroxy-3-methoxybenzalidene)-hydrazinecarboamide (HL3) have been synthesized and successfully confirmed their structures.[1,2,3]

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