Synthesis, antiapoptotic biological activity and structure of an oxo–vanadium(IV) complex with an OOO ligand donor set

Abstract

The oxo–vanadium(IV) complex VO(oda)(H 2O) 2 ( 1) (oda=oxydiacetate, O(CH 2COO −) 2) was obtained by reaction of aerobic aqueous solutions of VO(acac) 2 with oxydiacetic acid, O(CH 2COOH) 2. The antiapoptotic biological activity of 1 was studied in insulin-producing cells. Chemically generated nitric oxide (NO) triggers apoptotic events, such as the appearance of oligonucleosomes in cytosol, and this response was prevented by the presence of 1 in the culture medium. The molecular structure of 1 has been determined by X-ray diffraction analysis.