Abstract
Synthesis of Phenyl ethylene derivatives (4a-4f ) are reported in this communication. Products were characterized by1HNMR, Carbon (13C) NMR and Mass spectral data. Synthesized compounds of 4a-4f were screened for anti cancer and anti fungal activities and their results are presented. The main intermediate (3) was prepared from 4-methoxy phenyl acetone (1) reacted with aqueous ethylamine and NaBH4 to get the compound (2).Further dehydrohalogenation of (2) with 4-bromobutanol and potassium carbonate at 80°C resultedin compound (3)which on further dehydration with p-toluene sulfonic acid under reflux conditionsgave 4a to 4f.
Highlights
INTRODUCTIONEthylamine derivatives act as a musculotropic antispasmodic agent with a direct
Synthesis of Phenyl ethylene derivatives (4a-4f ) are reported in this communication
Phenyl ethylamine derivatives were found with very good biological activities viz., anticancer, antifungal
Summary
Ethylamine derivatives act as a musculotropic antispasmodic agent with a direct. Phenyl ethylamine derivatives were found with very good biological activities viz., anticancer, antifungal. In addition some of the phenyl action on the smooth muscle of the gastrointestinal tract (GIT) especially phenyl ethyl amine derived esters are found to be inhibiting. Besides the synthetic phenyl ethylamine and derivatives are ofgreat value in our daily life. The author focused on the synthesis of phenyl ethylene derivatives. These scaffolds and analogs are being subjected to biological screenings like antifungal and anti cancer activities
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