Abstract
Abstract A series of novel phenyl substituted side-chain analogues of classical cannabinoids were synthesized and their CB1 and CB2 binding affinities were evaluated relative to Δ 8 -THC and compound 2 . CB1 and CB2 binding assays indicate that the dimethyl and ketone analogues ( 3 ) and ( 6 ) display selectivity for the CB2 receptor in comparison to Δ 8 -THC and compound 2 . This study provides newer insights into the geometrical and functional group requirements of the ligand binding pockets of the CB1 and the CB2 receptors.
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