Abstract
The swelling behavior of novel pH- and temperature-sensitive interpenetrating polymer networks (IPNs) composed of poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAAc) in water was investigated. The PVA/PAAc IPN hydrogels were synthesized by UV irradiation, followed by a repetitive freezing and thawing process by which PVA hydrogel networks were formed inside of cross-linked PAAc chains. The swelling behaviors of these IPNs were analyzed in buffer solution at various pH and temperature ranges. Swelling ratios of all IPNs were relatively high, and they showed reasonable sensitivity to both pH and temperature. Hydrogels showed both the positive and negative swelling behaviors depending on PAAc content. IPN46 showed the positive temperature-sensitive swelling behaviors and its stepwise changes in swelling ratio was about 1.8 and 2.0 obtained between 25 and 45°C at pH 7, and between pH 4 and 7 at 35°C, respectively. The positive temperature dependence is attributed to the formation and dissociation of hydrogen bonding complexes between PVA and PAAc. These IPNs are expected to show a pH- and temperature-sensitive drug release according to the stepwise behavior at this temperature region. © 1996 John Wiley & Sons, Inc.
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