Abstract
A novel hexavanadate-based derivative covalently modified with glycine ethyl ester has been successfully synthesized via step-by-step functionalization. FT-IR, UV/visible, 1H NMR, ESI-MS spectrogram and single crystal X-ray diffraction were applied to certify the structure of the new compound. Moreover, this hybrid exhibited stronger inhibitory activity on human hepatocellular carcinoma tumor cells than the hexavanadate platform and even the universal commercial drug 5-fluorouracil. This work shows a broad prospect in the biochemical applications of polyoxovanadate-amino acid hybrids.
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