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https://doi.org/10.1016/j.bmcl.2012.03.039
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Cite Publication Date: Mar 16, 2012 | |
 Citations: 49 |
Affiliation: GlaxoSmithKline (United States), South College
A series of 1,2,4-triazolo[1,5-a]pyrimidin-7(3H)-ones with excellent enzyme inhibition, improved isoform selectivity, and excellent inhibition of downstream phosphorylation of AKT has been identified. Several compounds in the series demonstrated potent (∼ 0.100μM IC50) growth inhibition in a PTEN deficient cancer cell line.
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