Abstract
The derivatives of urea, thiourea and thiosemicarbazide play an important role in medicinal chemistry by influencing various pharmacological activities. The design and development of novel N-maltosides have emerged as an important class of organic compounds. A series of 1-hepta-O-benzoyl-β-D-Maltosyl- 5-aryl-2-4-thiobiurets are described in present work. By mixing hepta-O-benzoyl→D-maltosyl isocyanates with various aryl thiocarbamides, 1-hepta-O-benzoyl-β-D-maltosyl-5-aryl-2-4-thiobiurets have been synthesized. The identities of this newly synthesized 1-hepta-O-benzoyl-β-D-Maltosyl-5- aryl-2-4-thiobiurets were characterized by IR, 1H NMR and mass analyses. The compounds tested for antibacterial activity against a wide range of microorganisms, including Staphylococcus aureus, Escherichia coli, Psudomonas aeruginosa and antifungal activities against Aspergillus niger and Trichoderma. TLC confirmed the activity of these compounds.
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