Abstract
In this study we report the synthesis of a series of 2-Azetidinones from N-(4-(5-bromothiophen-2-yl)-6-(4-chlorophenyl)pyrimidin-2- yl)-1-(aryl) methanimine. A mixture of N-(4-(5-bromothiophen-2-yl)-6-(4-chlorophenyl)pyrimidin-2- yl)-1-(aryl) methanimine and triethyl amine was reacted with chloroacetyl chloride in 1,4-dioxane. The N-(4-(5-bromothiophen-2-yl)-6-(4 -chlorophenyl) pyrimidin-2- yl)-1-(aryl) methanimine was prepared from reaction of 4-(5-bromothiophene-2-yl)-6-(4-chloropheneyl)pyrimidin-2-amine with aromatic aldehydes in ethanol in presence of catalytic acetic acid. All newly synthesized compounds were characterized on the basis of 1H NMR, IR, and MASS spectral data.
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