Abstract
AbstractChloromethylstyrene–ethylene glycol dimethacrylate (EGDMA) copolymer beads (PCMS) and dimethylaminomethylstyrene‐EGDMA copolymer (PDAMS) were synthesized by suspension polymerization as noble polymer matrices. The chemical and physical properties of the quaternized resins (PCMS‐Q and PDAMS‐Q) were approximately equal. The characteristics of both resins were examined by high‐performance liquid chromatography using columns packed with the resins. These resins served as conventional anion‐exchange resins for small organic anions, but indicated markedly different retention for large molecular anions, namely, PDAMS‐Q retained proteins having a negative net charge, but PCMS‐Q did not. It was suggested that the chemical and physical structures on the external surfaces of ion exchangers are very important in ion‐exchange chromatography of proteins.
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