Abstract
This chapter takes a journey through the history of ion-exchange (IEX) chromatography of proteins. It covers a short introduction to adsorption models focusing on mechanistic concepts rather than mathematical modeling issues. The evolution of IEX resins is explored, covering soft or hydrophobic low-capacity resins in the early days to the current generation of robust, high-capacity media with fast mass transfer. The chapter also covers different perspectives on using IEX chromatography of proteins in industrial and academic research and development, showcasing diverse investigative approaches. Common modes of operations and their implementation in protein purification processes are presented. The chapter concludes with perspectives on future trends in IEX chromatography of proteins and other biomolecules.
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