Synthesis and properties of 2′–5′ and 3′–5′ linked α-oligoriboadenylates

Abstract

Uranyl ion-catalyzed oligomerization of α-adenosine 5′-phosphorimidazolide in neutral aqueous solution yielded 2′–5′ and 3′–5′ linked α-oligoriboadenylates. Spectroscopic properties of α-oligoriboadenylates were studied by NMR and CD. α-Oligoriboadenylates with 2′–5′ linkage showed strong resistance against nucleases, but weak binding ability to RNase L.