Synthesis and Pharmacological Evaluation of Promising Coumarin Methyl Ester/ Di/Tri/Tetra Peptide Derivatives

Abstract

Coumarin is a phenol, consisting of benzene ring and alpha-pyrone ring. Coumarins are prepared through Pechmann reaction, which involve condensation of phenol with ethyl acetoacetate in the presence of acid catalyst. Coumarins are being used widely due to their various biological activities in recent years, like anticoagulant, antibacterial, antitumoral, antitubercular, antifungal, MAO inhibitor activity, antioxidant, anti-inflammatory and as CNS active compounds. Methyl esters of amino acids and their di/tri and tetrapeptides derivatives were prepared using coupling agent DCC and a base NMM by stirring continuously for 36 hours. The compounds prepared were analyzed and the structures are elucidated by TLC, IR and 1H NMR spectral data. They were screened for antibacterial activity against three bacterial species and antifungal activity against one species