Synthesis and Investigation of Biological Activity of New Oxazinoazepines: Application of Fe3O4/CuO/ZnO@MWCNT Magnetic Nanocomposite in Reduction of 4-Nitrophenol in Water

Abstract

In this study, oxazinoazepine derivatives were synthesized in high yields using multicomponent reactions of aniline, oxalylchloride, alkyl bromides, activated acetylenic compounds, ethyl glycinate, and methyl epoxide in the presence of Fe3O4/CuO/ZnO@MWCNT as a high-performance catalyst in water at room temperature. The Fe3O4/CuO/ZnO@MWCNT was synthesized using Petasites hybridus rhizome water extract as a green media and moderate base. Also, the catalytic activity of the green synthesized Fe3O4/CuO/ZnO@MWCNT magnetic nanocomposits (MNCs) was evaluated in the reduction of organic pollutants such as 4-nitrophenol (4-NP) in water at mild conditions. The results indicated that the biosynthesized NCs have very high and effective catalytic activity for organic pollutants within few seconds. Investigation of antioxidant ability of synthesized compounds using radical trapping of diphenyl-picrylhydrazine (DPPH) and ferric reduction power experiment is another purpose in this research. Also, the antimicrobial activity of some synthesized compounds was proved by employing the disk diffusion test on Gram-positive and Gram-negative bacteria. This procedure has some benefits such as short reaction time, product with excellent yields, simple catalyst, and products separation.