Abstract
A new series of coumarin analogs (1a – 1g) were designed and synthesized. The chemical structures of all compounds were elucidated by IR, 1H NMR, 13C NMR, and mass spectroscopy techniques. The synthesized compounds were investigated for their anti-diabetic activity against streptozotocin (STZ) induced diabetes in rats. The albino rats were selected to observe the oral glucose tolerance test (OGTT) by oral intake of aqueous glucose solution (4 g/kg body weight) in normal rats and estimate the blood glucose level after administration of compounds 1e – 1f at 50 and 100 mg/kg, and standard drug glibenclamide at 0.6 mg/kg body weight. Antidiabetic activity was studied by estimating the blood glucose level in diabetic rats. The results showed that all the synthesized coumarin analogs 1a – 1g exhibited antidiabetic potential. Compounds 1e – 1f produced eminent antidiabetic effects in STZ induced diabetic rats.
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