Abstract
A rapid synthesis of the chlorofluorocarbon replacement compound 1,1,1,2-tetrafluoroethane (HFA-134a) was identified and utilized to prepare 99 + % radiochemically pure [ 18F]HFA-134a in 20–35% radiochemical yield. Four rats were then exposed to no-carrier-added (NCA) [ 18F]HFA-134a and monitored via coincidence detection. Following withdrawal of the test atmosphere of [ 18F]HFA-134a, the me an half-life of [ 18F]HFA-134a in four rats was determined to be 7.8 ± 1.5 min following a 10 s exposure and 8.1 ± 1.7 minutes following a 10 min exposure.
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