Synthesis and In-vitro Characterization of Celecoxib Emulgel

Abstract

The study was aimed at developing a topical preparation of Celecoxib, a COX inhibitor available in oral dosage form only, for localized and systemic effects. Initially, celecoxib containing microemulsion was developed using liquid paraffin, tween 20, water, methyl paraben, propyl paraben, menthol and clove oil. These components were incorporated into Carbopol 934 gel, with varying ratio to achieve stable emulgel formulation. The emulgel appeared as smooth white homogenized formulation having pH 6.6-6.8. The rheological properties showed pseudo plastic nature with yield stress. The spreadability and extrudability showed sufficient consistency for ease of processing, filling and application. Microbial assay showed no contamination to ensure the stability of formulation upon storage. Ex-vivo bio-adhesive strength and skin irritation test showed no irritation on rat skin. All these parameters suggested that emulgel can be explored and developed as an effective alternative formulation for the local and systemic application of celecoxib. various body tissues, connected by blood circulatory system. Another name for non-compartmental analysis is model-independent approach that means it does not require any compartment model.