Abstract
For precise delivery of 2-isopropyl-5-methylphenol (IPMP), Poly (lactic-co-glycolic acid) (PLGA) based superparamagnetic nanoparticles loaded with IPMP (IMNPs) were synthesized and characterized. IMNPs with a particle size of 223±20.7nm were synthesized by solvent evaporation method. Fe3O4 nanoparticles of 33±3.63nm encapsulated in the PLGA polymer provides the superparamagnetic property to the IMNPs. The entrapment efficacy of Fe3O4 nanoparticles, 2-isopropyl-5-methylphenol and average cumulative percentage release profile of IPMP from the IMNPs were investigated. The magnetic nanocarrier enhanced the stability and activity of IPMP. Release of IPMP from IMNPs occurred in a controlled manner. The cytotoxicity of IMNPs against human hepatoma Hep3B cell line was investigated and the IC50 value was found to be 20μg/mL for IMNPs compared to 25μg/mL for free IPMP. The result showed that IMNPs had significant antitumor activity. Therefore, IMNPs may be considered as an effective anticancer drug delivery system for cancer chemotherapy.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
