Abstract
In the present study we report the synthesis and antibacterial activity of a new series 2‐(1‐methyl‐4‐nitro‐1H‐imidazol‐5‐ylsulfonyl)‐1,3,4‐thiadiazoles (6a-c). Compounds 6a-c were tested in vitro by the conventional agar dilution method against a panel of microorganisms including gram‐negative and gram‐positive bacteria. Compound 6b with 5‐(5‐nitrofuran‐2‐yl)‐residue on 1,3,4‐thiadiazole scaffold have shown promising antibacterial activities against gram‐positive bacteria including Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis.
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