Abstract
Eleven oxazolone derivatives were synthesized and characterized by 1H NMR, EI, IR and UV spectroscopic and CHN analysis. Three compounds, 4-[( E)-(4-nitrophenyl)methylidene]-2-phenyl-1,3-oxazol-5(4 H)-one ( 11), 4-[( E)-(4-methoxyphenyl)methylidene]-2-methyl-1,3-oxazol-5-one ( 12) and 4-[( E)-(4-nitrophenyl)methylidene]-2-methyl-1,3-oxazol-5(4 H)-one ( 13) were screened for phagocyte chemiluminescence, neutrophil chemotaxis, T-cell proliferation, cytokine production from mononuclear cells and cytotoxicity. 4-[( E)-(4-Nitrophenyl)methylidene]-2-methyl-1,3-oxazol-5(4 H)-one ( 13) was found to be the most potent immunomodulator in the series.
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